Center for Precision Imaging

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    Tumor Receptor Imaging

    Tumor Receptor Imaging

    An EGFR Targeted PET Imaging Probe for the Detection of Colonic Adenocarcinomas

    An EGFR Targeted PET Imaging Probe for the Detection of Colonic Adenocarcinomas

    Theranostics. 2014; 4(9): 893–903. Colorectal cancer is a serious complication associated with inflammatory bowel disease, often...
    PET imaging of glioblastoma multiforme EGFR expression for therapeutic decision guidance

    PET imaging of glioblastoma multiforme EGFR expression for therapeutic decision guidance

    Am J Nucl Med Mol Imaging. 2015; 5(4): 379–389. After initial therapy and total resection of glioblastoma multiforme (GBM), 80-90% of...
    18 F-FES PET/CT Measurement of ER Suppression during a Phase I Trial of GDC-0810

    18 F-FES PET/CT Measurement of ER Suppression during a Phase I Trial of GDC-0810

    Clin Cancer Res; 23(12); 3053-60. Purpose: Evaluate 18F-fluoroestradiol (FES) PET/CT as a biomarker of estrogen receptor (ER) occupancy...
    A phase one, single-dose, open-label, clinical safety and PET/MR imaging study of 68 Ga-DOTATOC

    A phase one, single-dose, open-label, clinical safety and PET/MR imaging study of 68 Ga-DOTATOC

    Am J Nucl Med Mol Imaging. 2017; 7(2): 53–62. This prospective pilot study provides a dynamic whole body PET/MR image database, clinical...
    Synthesis and preliminary PET imaging of  of the ROS1/ALK inhibitor lorlatinib

    Synthesis and preliminary PET imaging of of the ROS1/ALK inhibitor lorlatinib

    Nat Commun. 2017 Jun 8;8:15761. Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine...
    Specific 18F-FDHT Accumulation in Human Prostate Cancer Models Is Facilitated by Prebinding to SHBG

    Specific 18F-FDHT Accumulation in Human Prostate Cancer Models Is Facilitated by Prebinding to SHBG

    J Nuclear Med. 2018 Apr;20(2):300-308. Purpose: Tremendous efforts are currently dedicated to the development of novel therapies...
    Phage Display Selection, In Vitro Characterization, and Correlative PET Imaging of a HER3 Peptide

    Phage Display Selection, In Vitro Characterization, and Correlative PET Imaging of a HER3 Peptide

    Mol Imaging Biol. 2018 Apr;20(2):300-308. HER3 (ERBB3) is a receptor tyrosine kinase that is implicated in treatment resistance across...
    Differential Receptor Tyrosine Kinase PET Imaging for Therapeutic Guidance

    Differential Receptor Tyrosine Kinase PET Imaging for Therapeutic Guidance

    J Nucl Med. 2016 Sep;57(9):1413-9. Purpose: Inhibitors of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of...
    HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib

    HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib

    Mol Imaging Biol. 2021 Jun 8. Purpose: Standard therapy for HER2+ breast cancers includes HER2 inhibition. While HER2 inhibitors have...
    HER3 Differentiates Basal From Claudin Type TNBC and Contributes to Drug Resistance

    HER3 Differentiates Basal From Claudin Type TNBC and Contributes to Drug Resistance

    Front Oncol. 2020 Nov 20;10:554704. Triple Negative Breast Cancer (TNBC) is an aggressive form of Breast Cancer (BC). Numerous kinase...
    Optical Imaging of MET for Enhanced Detection and Characterization of Hepatic Tumors

    Optical Imaging of MET for Enhanced Detection and Characterization of Hepatic Tumors

    Theranostics. 2016 Sep 9;6(12):2028-2038. Purpose: To assess optical imaging of Mesenchymal-Epithelial Transition factor (MET) for...
    Somatostatin receptor type 2 as a radiotheranostic PET reporter gene for oncologic interventions

    Somatostatin receptor type 2 as a radiotheranostic PET reporter gene for oncologic interventions

    Theranostics. 2018 May 23;8(12):3380-3391. Purpose: Reporter gene systems can serve as therapy targets. However, the therapeutic use of...
    Pharmacodynamic imaging guides dosing of a selective estrogen receptor degrader

    Pharmacodynamic imaging guides dosing of a selective estrogen receptor degrader

    Clin Cancer Res. 2015 Mar 15;21(6):1340-7. Purpose: Estrogen receptor (ER) targeting is key in management of receptor-positive breast...
    Free SSTR fraction predicts the antiproliferative effect of octreotide in NETs

    Free SSTR fraction predicts the antiproliferative effect of octreotide in NETs

    Cancer Res. 2013 Dec 1;73(23):6865-73. Somatostatin receptors (SSTR) are highly expressed in well-differentiated neuroendocrine tumors...

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