Immune System /Tumor Microenvironment

Immune System /Tumor Microenvironment Imaging

Fluorescent Nanoparticle Imaging Allows Noninvasive Evaluation of Immune Cell Modulation

Mol Imaging. 2014 May; 13(3): 1–11. Esophageal tumors provide unique challenges and opportunities for developing and testing surveillance...

Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems

ACS Nano. 2013 Mar 26; 7(3): 2032–2041. Attaching DNA binding fluorochromes to nanoparticles (NPs) provides a way of obtaining NPs that...

Analysis of osteoarthritis development in a mouse model by serial NIRF imaging of MMP activities

Arthritis Rheumatol. 2015 Feb; 67(2): 442–453. Objective: A major hurdle in osteoarthritis (OA) research is the lack of sensitive...

Optical imaging of periostin for endoscopic detection and characterization of esophageal cancer

Gastroenterology. 2013 Feb; 144(2): 294–297. Imaging strategies that detect early stage esophageal squamous cell carcinoma (ESCC) could...

Imaging of Secreted ECM Periostin, a Marker of Invasion in the Tumor Microenvironment

Journal of Nuclear Medicine August 2015, 56 (8) 1246-1251. Background: Periostin, an extracellular matrix protein, plays key role in...

Quantitative CD3 PET Imaging Predicts Tumor Growth Response to Anti-CTLA-4 Therapy

J Nucl Med. 2016 Oct; 57(10): 1607–1611. Background: Immune checkpoint inhibitors have made rapid advances, resulting in multiple Food...

Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding ICI response

J Immunother Cancer. 2020 May;8(1):e000291. Background: Cancer immunotherapy research is expanding to include a more robust understanding...

The Effectiveness of ICI Combinations and Timing Can Be Measured by Granzyme B

Clin Cancer Res. 2019 Feb 15;25(4):1196-1205. Purpose: The lack of a timely and reliable measure of response to cancer immunotherapy has...

Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response

Cancer Res. 2017 May 1;77(9):2318-2327. While cancer immunotherapy can produce dramatic responses, only a minority of patients respond to...