Metabolic Imaging

Therapeutic efficacy and fate of bimodal engineered stem cells in malignant brain tumors

Stem Cells. 2013 Aug; 31(8): 1706–1714. Therapeutically engineered stem cells (SC) are emerging as an effective tumor-targeted approach...

18 F-Fluciclovine PET in Men With BCR PCa after Prostatectomy and planning for Salvage Radiation

Pract Radiat Oncol. Sep-Oct 2020;10(5):354-362 Purpose: Conventional imaging rarely localizes the site(s) of prostate cancer recurrence...

C11 Methionine PET (MET-PET) Imaging of Glioblastoma for Detecting Postoperative Residual Disease

Int J Radiat Oncol Biol Phys. 2018 Nov 15; 102(4): 1024–1028. Purpose: Response criteria of glioblastoma after chemoradiation do not...

The Impact of PET with 18F-Fluciclovine on the Treatment of BCR of PCa: Results from the LOCATE Tria

J Urol. 2019 Feb; 201(2): 322–331. Purpose: The prospective, multicenter LOCATE (F Fluciclovine [FACBC] PET/CT in Patients with Rising...

Genotype directed therapy in murine mismatch repair deficient tumors

Am J Nucl Med Mol Imaging. 2017; 7(2): 53–62. The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that...

Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery

Clin Cancer Res. 2013 Jun 1;19(11):2929-40. Purpose: Effective therapies for KRAS-mutant colorectal cancer (CRC) are a critical unmet...

Tumor Hypoxia Response After Targeted Therapy in EGFR-Mutant Non-Small Cell Lung Cancer

Technol Cancer Res Treat. 2016 Apr; 15(2): 234–242. Hypoxia is associated with resistance to radiotherapy and chemotherapy. Functional...

Depletion of CAFs and fibrosis induces immunosuppression and accelerates pancreas cancer

Cancer Cell. 2014 Jun 16;25(6):719-34. Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal...

Metformin divergently modulates tumor metabolism and proliferation

J Nucl Med. 2013 Feb;54(2):252-8. Purpose: Over the last several years, epidemiologic data have suggested that the antidiabetes drug...

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

EMBO Mol Med. 2014 Apr;6(4):519-38. 5′AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus...

Inhibition of de novo lipogenesis targets androgen receptor signaling in prostate cancer

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):631-640. A hallmark of prostate cancer progression is dysregulation of lipid metabolism via...