Center for Precision Imaging

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    Metabolic Imaging

    Metabolic Imaging

    Therapeutic efficacy and fate of bimodal engineered stem cells in malignant brain tumors

    Therapeutic efficacy and fate of bimodal engineered stem cells in malignant brain tumors

    Stem Cells. 2013 Aug; 31(8): 1706–1714. Therapeutically engineered stem cells (SC) are emerging as an effective tumor-targeted approach...

    18 F-Fluciclovine PET in Men With BCR PCa after Prostatectomy and planning for Salvage Radiation

    Pract Radiat Oncol. Sep-Oct 2020;10(5):354-362 Purpose: Conventional imaging rarely localizes the site(s) of prostate cancer recurrence...
    C11 Methionine PET (MET-PET) Imaging of Glioblastoma for Detecting Postoperative Residual Disease

    C11 Methionine PET (MET-PET) Imaging of Glioblastoma for Detecting Postoperative Residual Disease

    Int J Radiat Oncol Biol Phys. 2018 Nov 15; 102(4): 1024–1028. Purpose: Response criteria of glioblastoma after chemoradiation do not...
    The Impact of PET with 18F-Fluciclovine on the Treatment of BCR of PCa: Results from the LOCATE Tria

    The Impact of PET with 18F-Fluciclovine on the Treatment of BCR of PCa: Results from the LOCATE Tria

    J Urol. 2019 Feb; 201(2): 322–331. Purpose: The prospective, multicenter LOCATE (F Fluciclovine [FACBC] PET/CT in Patients with Rising...
    Genotype directed therapy in murine mismatch repair deficient tumors

    Genotype directed therapy in murine mismatch repair deficient tumors

    Am J Nucl Med Mol Imaging. 2017; 7(2): 53–62. The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that...
    Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery

    Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery

    Clin Cancer Res. 2013 Jun 1;19(11):2929-40. Purpose: Effective therapies for KRAS-mutant colorectal cancer (CRC) are a critical unmet...
    Tumor Hypoxia Response After Targeted Therapy in EGFR-Mutant Non-Small Cell Lung Cancer

    Tumor Hypoxia Response After Targeted Therapy in EGFR-Mutant Non-Small Cell Lung Cancer

    Technol Cancer Res Treat. 2016 Apr; 15(2): 234–242. Hypoxia is associated with resistance to radiotherapy and chemotherapy. Functional...
    Depletion of CAFs and fibrosis induces immunosuppression and accelerates pancreas cancer

    Depletion of CAFs and fibrosis induces immunosuppression and accelerates pancreas cancer

    Cancer Cell. 2014 Jun 16;25(6):719-34. Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal...
    Metformin divergently modulates tumor metabolism and proliferation

    Metformin divergently modulates tumor metabolism and proliferation

    J Nucl Med. 2013 Feb;54(2):252-8. Purpose: Over the last several years, epidemiologic data have suggested that the antidiabetes drug...
    A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

    A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

    EMBO Mol Med. 2014 Apr;6(4):519-38. 5′AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus...
    Inhibition of de novo lipogenesis targets androgen receptor signaling in prostate cancer

    Inhibition of de novo lipogenesis targets androgen receptor signaling in prostate cancer

    Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):631-640. A hallmark of prostate cancer progression is dysregulation of lipid metabolism via...

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