All living cells need energy and building blocks such as sugars, lipids, nucleic acids, and amino acids. With disease and with response to treatment, metabolic changes often precedes anatomic alterations.
Changes in metabolism are seen in cancer, cardiovascular disease, autoimmunity, and neurodegeneration. Moreover, modulating cellular metabolism is of growing interest as a vital and complementary approach in cancer treatment. We have imaged the diverse cellular building blocks in both murine models and in humans to improve disease detection, monitor response to therapy, and to help define optimal therapeutic targets in various scenarios.
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