Optical molecular imaging devices enable minimally invasive procedure for diagnosis and therapy of cancer.
Our group has developed and translated devices to improve interventional procedures, including optical fluorescence guidance of percutaneous biopsies. More recently, we have applied this experience to increase our understanding of the effects of cryoablation on immune-tumor interactions, both at the site of treatment as well as at distant tumor sites. Optical imaging probes we have published on include those targeting specific enzyme overexpression, immune cell upregulation, cell surface receptors, extracellular matrix components, and metabolic changes.
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